ZEBRAFISH IGF GENES: GENE DUPLICATION, CONSERVATION AND DIVERGENCE, AND NOVEL ROLES IN MIDLINE AND NOTOCHORD DEVELOPMENT.

Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development.

Insulin-like growth factors (IGFs) are key regulators Footmuff of development, growth, and longevity.In most vertebrate species including humans, there is one IGF-1 gene and one IGF-2 gene.Here we report the identification and functional characterization of 4 distinct IGF genes (termed as igf-1a, -1b, -2a, and -2b) in zebrafish.These genes encode 4

read more